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109770-29-8

中文名称 BETA-AMYLOID (1-28)
英文名称 H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS 109770-29-8
分子式 C145 H209 N41 O46
分子量 3262.46
MOL 文件 109770-29-8.mol
更新日期 2024/05/19 20:37:19
109770-29-8 结构式 109770-29-8 结构式

基本信息

中文别名
Β淀粉样蛋白(1-28)
AMYLOID Β肽(1-28)
Β淀粉样肽(1-28)单克隆抗体
Β淀粉样肽1-28/Β-AMYLOID 1-28抗体
英文别名
SP28
Fam-β-Amyloid
β-Amyloid (1-28)
BETA-AMYLOID (1-28)
AMyloid b-Protein (1-28)
AMYLOID BETA-PROTEIN (1-28)
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
AMYLOID, BETA- (1-28), HUMAN
[Gln11] -β- Amyloid (1 - 28)
Human β-amyloid peptide(1-28)
所属类别
生物化工:多肽

物理化学性质

密度1.52±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度Soluble in DMSO
形态白色冻干粉末。
序列H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

安全数据

WGK Germany3
BETA-AMYLOID (1-28)价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2023/03/20HY-P1468BETA-AMYLOID (1-28)
β-Amyloid (1-28)
109770-29-81mg1600元
2023/03/20HY-P1468BETA-AMYLOID (1-28)
β-Amyloid (1-28)
109770-29-85mg6400元

常见问题列表

生物活性
β-Amyloid (1-28) 是可参与金属结合的β-淀粉样蛋白片段。β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。
靶点

Amyloid-β

体外研究

β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.

体内研究

β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu 2+ interaction. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K a 10 7 M -1 .

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