112208-00-1
中文名称
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
英文名称
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
CAS
112208-00-1
分子式
C81H156N10O13S
分子量
1510.23
MOL 文件
112208-00-1.mol
更新日期
2024/05/19 20:37:18
112208-00-1 结构式
基本信息
中文别名
PAM?CYS-SER-(LYS)?,盐酸盐S-[2,3-二[(1-氧代十六烷基)氧基]丙基]-N-(1-氧代十六烷基)-L-半胱氨酰基-L-丝氨酰基-L-赖氨酰基-L-赖氨酰基-L-赖氨酰基-L-赖氨酸
(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-2-[[(2R)-3-[2,3-DI(HEXADECANOYLOXY)PROPYLSULFANYL]-2-(HEXADECANOYLAMINO)PROPANOYL]AMINO]-3-HYDROXYPROPANOYL]AMINO]HEXANOYL]AMINO]HEXANOYL]AMINO]HEXANOYL]AMINO]HEXANOIC ACID
英文别名
sineP 3C
Pam3CSK4
Pam3CSK41
Pam3CysSK4
Pam3Cys-SKKKK
Pam3Cys-Ser-(Lys)4
PaM3Cys-Ser-(Lys)4 . 3HCl
PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH
PamCys-Ser-(Lys), Hydrochloride
物理化学性质
沸点1408.0±65.0 °C(Predicted)
密度1.054±0.06 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble to 1 mg/ml in 50% Ethanol / H2O
酸度系数(pKa)3.27±0.10(Predicted)
形态冻干固体
常见问题列表
用途
本品主要用于实验室有机合成中和化工医药研发过程中。生物活性
Pam3CSK4 是一种 Toll 样受体 1/2 (TLR1/2) 激动剂，对人 TLR1/2 的 EC50 为 0.47 ng/mL。体外研究
Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant
Staphylococcus aureus
.
体内研究
Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.
| Animal Model: | Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2 tm1Kir /J (TLR2 -deficient) mice |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneally (i.p.); once a day for 9 days |
| Result: | After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12. |