118525-40-9
118525-40-9 结构式
基本信息
三七淫羊藿素
脱水淫羊藿黄素
去水淫羊藿黄素
淫羊藿素(标准品)
去水淫羊藿黄素, >98%
淫羊藿苷杂质2(脱水淫羊藿素)
去水淫羊藿黄素(G级现货,剩余原料)
ANHYDROICARITIN 脱水淫羊藿素
ANHYDROICARITIN 脱水淫羊藿素 标准品
Icaritin>
Icaritin, >98%
Icaritin(Anhydroicaritin)
Icariin Impurity 2 (Icaritin)
3,7-bis(2-hydroxyethyl)icaritin
3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
物理化学性质
常见问题列表
Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells .
Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner.
Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells.
Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1.
Cell Proliferation Assay
| Cell Line: | K562, imatinib-resistant cells and primary CML cells |
| Concentration: | 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell proliferation. |
Apoptosis Analysis
| Cell Line: | K562 or primary cells |
| Concentration: | 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Induced K562 or primary cells apoptosis. |
Cell Cycle Analysis
| Cell Line: | K562 cells |
| Concentration: | 32 µM |
| Incubation Time: | |
| Result: | Cell population in the sub-G1 phase was increased. |
Western Blot Analysis
| Cell Line: | K562 cells |
| Concentration: | 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. |
Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model.
| Animal Model: | Female NOD-SCID nude mice (6-8 weeks old) with K562 cells |
| Dosage: | 4 mg/kg and 8 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 10 weeks |
| Result: | Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow. |