1190308-01-0
中文名称
索非布韦R-磷酸盐
英文名称
PSI-7976
CAS
1190308-01-0
分子式
C22H29FN3O9P
分子量
529.45
MOL 文件
1190308-01-0.mol
更新日期
2024/05/16 11:48:17
1190308-01-0 结构式
基本信息
中文别名
磷异构体索氟布韦杂质6
索非布韦杂质19
索非布韦杂质01
索福斯布韦杂质A
Y008005-A
索非布韦R-磷酸盐
PSI-7976/ PSI7977杂质A
英文别名
PSI-7976SFB-L-Alaninate-Model
Sofosbuvir (R)-Phosphate
Sofosbuvir phosphate salt
N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester
L-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alanite
isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-Lalaninate
(S)-isopropyl 2-((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
Sofosbuvir impurity 14/ RP-Isomer of Sofosbuvir/Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
物理化学性质
熔点76-82°C
密度1.41±0.1 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度可溶于氯仿（少量）、DMSO（少量）、乙酸乙酯（少量）
酸度系数(pKa)9.39±0.10(Predicted)
形态固体
颜色白色至灰白色
