129580-63-8
中文名称
顺式-二氯-反式-二乙酸-氨-环己胺合铂
英文名称
Satraplatin
CAS
129580-63-8
分子式
C10H22Cl2N2O4Pt
分子量
500.28
MOL 文件
129580-63-8.mol
更新日期
2024/05/21 17:53:46
129580-63-8 结构式
基本信息
中文别名
赛特铂塞特铂
顺式-二氯-反式-二乙酸-氨-环己胺合铂
顺式-二氯-反式-二乙酸-顺式-氨,环己胺合铂(IV)
英文别名
JM 216C081294
BMY 45594
BMS 182751
SATRAPLATIN
Satraplatin(JM216)
BMS-182751
BMY-45594
JM-216
bis(acetato-o)amminedichloro(cyclohexanamine)-pt
Bis-acetatoamminedichlorocyclohexylamine platinum(iv)
(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
常见问题列表
生物活性
Satraplatin 是一种烷化剂 (alkylator)，具有抗肿瘤效果。体外研究
Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC 50 of 1.36 ± 0.11 μM. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC 50 , 7.04 μM), and causes G2/M arrest in KB-R cells.