130-01-8
基本信息
千里光宁碱
千里光寧鹼
千里光碱/ 千里光宁
Aureine
SENECIONIN
Sencionine
SENECIONINE
Senecionine/Aureine
16-dione,12-hydroxy-senecionan-1
12-Hydroxysenecionan-11,16-dione
Senecionan-11,16-dione, 12-hydroxy-
(15cis)-12-Hydroxysenecionan-11,16-dione
物理化学性质
安全数据
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 1mg | 860元 |
2024/04/30 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 5mg | 2600元 |
2024/04/30 | HY-N2560 | 千里光宁 Senecionine | 130-01-8 | 10mg | 4100元 |
常见问题列表
Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.