134615-37-5
134615-37-5 结构式
基本信息
中文别名
雷弗霉素 A 英文别名
REVEROMYCIN AZESGNAJSBDILTB-OXVOKJAASA-N
Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
物理化学性质
沸点849.0±65.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度DMF: soluble
酸度系数(pKa)4.36±0.17(Predicted)
形态solid
颜色tan
常见问题列表
生物活性
Reveromycin A 是一种从链霉菌属中分离出来的苯甲醌类抗生素 (antibiotic)，是选择性的真核细胞中蛋白质合成 (protein synthesis) 抑制剂。Reveromycin A 通过诱导破骨细胞的凋亡 (apoptosis) 来抑制骨吸收。Reveromycin A 对肿瘤细胞系具有抗增殖活性，并具有抗真菌 (antifungal) 活性。体外研究
Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase.
Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis.
体内研究
Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats.