137339-65-2
基本信息
凝血酶受体兴奋剂
凝血酶受体活化因子肽
凝血酶受体激动剂肽-14
TRAP3
CD40LG
TNFSF5
TRAP-14
HUMAN TRAP
HUMAN GP39
MGC: 45012
HUMAN CD154
HUMAN T-BAM
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | XW13733965202 | 凝血酶受体兴奋剂 | 137339-65-2 | 5MG | 837元 |
2024/04/30 | HY-P1000 | 凝血酶受体兴奋剂 Sfllrnpndkyepf | 137339-65-2 | 1mg | 900元 |
2024/04/30 | XW13733965203 | 凝血酶受体兴奋剂 | 137339-65-2 | 25MG | 2420元 |
常见问题列表
Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence Sfllrnpndkyepf. This peptide (TRP-14) may signal a variety of thrombin's responses. Sfllrnpndkyepf, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. Sfllrnpndkyepf, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. Sfllrnpndkyepf is the minimal peptide length which retains full activity in inducing [ 14 C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.