13849-91-7
13849-91-7 结构式
基本信息
中文别名
坡模酸坡模醇酸
兰地酸A
坡模醇酸,坡模酸
英文别名
POMOLIC ACIDBenthamic acid
Randialic acid A
3β,19-Dihydroxyurs-12-en-28-oic acid
3β,19α-Dihydroxyurs-12-ene-28-oic acid
3β,19-Dihydroxy-5α-urs-12-en-28-oic acid
Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)-
所属类别
天然产物：萜类物理化学性质
熔点297-299 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
沸点586.2±50.0 °C(Predicted)
密度1.14±0.1 g/cm3(Predicted)
储存条件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)4.48±0.70(Predicted)
形态粉末
常见问题列表
生物活性
Randialic acid A (Pomolic acid) 是一种五环三萜烯，是从 Euscaphis japonica 中分离出来的。Randialic acid A (Pomolic acid) 抑制肿瘤细胞的生长并诱导细胞凋亡。 Randialic acid A (Pomolic acid) 有用于前列腺癌的潜力。靶点
IC50: apoptosis
体外研究
Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.