142001-63-6
142001-63-6 结构式
基本信息
中文别名
化合物 T16842 英文别名
SR 48968Sr 48968c
(S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide
Benzamide, N-((2S)-4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-
Benzamide, N-(4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-, (S)-
物理化学性质
沸点734.7±60.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 250 mg/mL (452.46 mM)
酸度系数(pKa)15.88±0.20(Predicted)
常见问题列表
生物活性
Saredutant 是一种选择性 NK2 受体拮抗剂。靶点
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NK2
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体内研究
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility.