1442684-77-6
中文名称
AM2394
英文名称
AM2394
CAS
1442684-77-6
分子式
C22H25N5O4
分子量
423.46
MOL 文件
1442684-77-6.mol
更新日期
2024/06/05 13:45:43
1442684-77-6 结构式
基本信息
中文别名
化合物AM2394 英文别名
AM2394CS-2242
AM2394
AM 2394
N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点588.8±50.0 °C(Predicted)
密度1.266±0.06 g/cm3(Predicted)
储存条件Inert atmosphere,Room Temperature
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
酸度系数(pKa)12.66±0.70(Predicted)
形态结晶固体
常见问题列表
用途
AM 2394是一种结构独特的葡萄糖激酶激活剂(GKA)。AM-2394通过一个60 nM的EC50激活GK。生物活性
AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK)，EC50 为 60 nM。靶点
EC50: 60 nM (glucokinase)
体内研究
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.