16506-27-7
16506-27-7 结构式
基本信息
苯达莫司汀
4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
盐酸苯达莫司汀/4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
4-(5-(Bis(2-chloroethyl)
-1-methyl-1H-benzo[d]imidazol-2-yl)
5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid
5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-
4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | S5939 | 宾达氮芥 Bendamustine | 16506-27-7 | 5mg | 959.1元 |
| 2024/04/30 | S5939 | 宾达氮芥 Bendamustine | 16506-27-7 | 25mg | 3661.33元 |
| 2024/01/16 | S5939 | Bendamustine (SDX105) | 16506-27-7 | 10mM (1mL in DMSO) | 1122.03元 |
常见问题列表
DNA Alkylator/Crosslinker
Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC
25
s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.
Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.