17528-72-2
17528-72-2 结构式
基本信息
(6R,S)-5,6,7,8-四氢-L-生物蝶呤二盐酸盐
6R-BH4
THB, 2HCL
(6R)-BH4 2HCL
BH4 DIHYDROCHLORIDE
Tetrahydrobiopterin
5,6,7,8-Tetrahydrobiopterin
TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE
(6R)-5,6,7,8-TETRAHYDRO-BIOPTERIN DIHYDROCHLORIDE
(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
物理化学性质
安全数据
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-107383 | 四氢生物喋呤 Tetrahydrobiopterin | 17528-72-2 | 5mg | 1125元 |
| 2024/04/30 | HY-107383 | 四氢生物喋呤 Tetrahydrobiopterin | 17528-72-2 | 10mM * 1mLin DMSO | 1238元 |
| 2024/04/30 | HY-107383 | 四氢生物喋呤 Tetrahydrobiopterin | 17528-72-2 | 10mg | 1800元 |
常见问题列表
|
Human Endogenous Metabolite
|
MicMicroglial cell cultures under hyperoxia are supplemented or not with an effective dose of Tetrahydrobiopterin (BH4) (100 μM). Exposure of microglial cells to hyperoxia-induced oxidative stress for 24 h reveals a robust increase in TSP-1 mRNA expression and protein compare to normoxia (21% O 2 ). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation by diminishing Iba-1 and TSP-1 expression and prevents microvascular injury in choroidal explants.
To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively.