17575-22-3
中文名称
毛花苷C
英文名称
LANATOSIDE C
CAS
17575-22-3
分子式
C49H76O20
分子量
985.12
MOL 文件
17575-22-3.mol
更新日期
2024/05/20 09:24:27
17575-22-3 结构式
基本信息
中文别名
毛花苷C毛花甙丙
毛花洋地黄苷
毛花洋地黄甙丙
地高辛EP杂质H
去乙酰毛花洋地黄甙
去乙酰基毛花洋地黄甙
地高辛杂质H(EP)
毛花苷C(甄准不供应)
毛花甙C(地高辛杂质H)
英文别名
AllocorCelanid
isolanid
Ceglunat
Celanide
NSC 7533
isolanide
cedilanid
Ceglunate
Celadigal
所属类别
原料药：抗充血性心力衰竭药物理化学性质
熔点272-274°C
比旋光度D20 +33.4 to +33.7° (200 mg dry weight in 10 ml alcohol)
沸点741.7°C (rough estimate)
密度1.42±0.1 g/cm3 (20 ºC 760 Torr)
折射率1.7630 (estimate)
储存条件-20°C
溶解度DMSO:50.0(Max Conc. mg/mL);50.75(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);2.03(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);2.03(Max Conc. mM)
酸度系数(pKa)12.89±0.70(Predicted)
形态固体
颜色白色至灰白色
稳定性吸湿性
LogP0.070
安全数据
警示词危险
危险性描述H301-H330-H373
危险品标志T
危险类别码23/24/25
安全说明36/37/39-45
危险品运输编号UN 2811 6.1/PG 2
WGK Germany3
RTECS号OE2100000
常见问题列表
生物活性
Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK，Wnt，JAK-STAT和PI3K/AKT/mTOR信号通路，诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。体外研究
Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71. Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.