17696-69-4
中文名称
血卟啉二盐酸盐
英文名称
HEMATOPORPHYRIN DIHYDROCHLORIDE
CAS
17696-69-4
分子式
C34H40Cl2N4O6
分子量
671.61
MOL 文件
17696-69-4.mol
更新日期
2024/04/28 11:46:18
17696-69-4 结构式
基本信息
中文别名
盐酸血紫质盐酸血紫素
血紫素盐酸盐
血卟啉盐酸盐
二盐酸血紫素
血卟啉二盐酸盐
卤代卟啉盐酸盐
一水合二盐酸血卟啉
血卟啉IX二氯化氢
血卟啉盐酸盐(一水)
英文别名
ematoporfirinaHemaloporphyrin
HematoporphyrineDihcl
HAEMATOPORPHYRINDICHLORIDE
Haematopophyrin dihydrochloride
HEMATOPORPHYRIN DIHYDROCHLORIDE
HAEMATOPORPHYRIN DIHYDROCHLORIDE
HEMATOPORPHYRIN IX DIHYDROCHLORIDE
HAEMATOPORPHYRIN Dihydrochloride(RG)
HEMATOPORPHYRIN DIHYDROCHLORIDE USP/EP/BP
所属类别
原料药：抗抑郁、躁狂药物理化学性质
储存条件2-8°C
溶解度DMSO (Slightly), Methanol (Slightly)
形态Solid
颜色Very Dark Red
水溶解性Insoluble in water. Soluble in pyridine (5%).
Merck14,4636
BRN78957
稳定性Hygroscopic
安全数据
警示词警告
危险性描述H302-H315-H319-H335
危险类别码33
RTECS号TS5505000
TSCAYes
毒性mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978.
常见问题列表
应用
有研究表明血卟啉二盐酸盐可用于制备具有高结晶速率的树脂组合物，其包含聚呋喃二甲酸亚烷基酯(polyalkylenefurandicarboxylate)树脂和卟啉化合物。该聚呋喃二甲酸亚烷基酯树脂优选为聚呋喃二甲酸亚丁基酯树脂。该卟啉化合物优选为血卟啉二盐酸盐(hematoporphyrindihydrochloride)。生物活性
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。当暴露于红光下时，Hematoporphyrin dihydrochloride 可以诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。体外研究
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC
50
s of 85 and 166 nM, respectively.
Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.
Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
Cell Viability Assay
| Cell Line: | U87 and U251 cells |
| Concentration: | 20, 40, 60, 80, 100, 120 nM |
| Incubation Time: | 60 min |
| Result: |
Inhibited cell viability in a dose-dependent manner.
Was more effective under the red light than white light. |
Apoptosis Analysis
| Cell Line: | U87 cells |
| Concentration: | 85 nM |
| Incubation Time: | 60 min |
| Result: |
Induced apoptotic nuclei in U87 cells with low cell density.
Induced the ROS and decreased the mitochondrial membrane potential. |
体内研究
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.
| Animal Model: | Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130 |
| Dosage: | 5, 10 mg/kg |
| Administration: | I.p. daily during the initial 10 days and biweekly for the next 2 months |
| Result: |
No tumor could be palpated a few days after exposure of the rats to light.
The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40). |