20311-51-7
中文名称
澳洲茄边碱
英文名称
Solamargine
CAS
20311-51-7
分子式
C45H73NO15
分子量
868.06
MOL 文件
20311-51-7.mol
更新日期
2024/05/22 10:39:06
20311-51-7 结构式
基本信息
中文别名
边缘茄碱澳州茄边碱
Α-奥洲边茄碱
澳洲茄边碱(标准品)
澳洲茄边碱, >98%
澳洲茄边碱(奥洲边茄碱)
Α-SOLAMARGINE
英文别名
SolamarginNSC 407810
SOLAMERGINE
δ-Solanigrine
α-Solamargine
Solamargine, >98%
Solamargine 20311-51-7
2)-O-[6-deoxy-a-L-Mannopyranosyl-(1®
b-D-Glucopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®
spirosol-5-en-3-yl 6-deoxyhexopyranosyl-(1->2)-[6-deoxyhexopyranosyl-(1->4)]hexopyranoside
所属类别
天然产物：生物碱物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于澳洲茄 Solanum aviculare Forst.果实。
熔点301 °C
密度1.38
储存条件Refrigerator
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)12?+-.0.70(Predicted)
形态固体
颜色浅米色
常见问题列表
简介
澳洲茄边碱是从茄属植物中分离得到的一种甾体生物碱。澳洲茄边碱可以与c3样蛋白酶(SARS-CoV-2主蛋白酶)的氨基酸Phe8、Pro9、Ile152、Tyr154、Pro293、Phe294、Val297和Arg298相互作用。其来源于龙葵SolanumnigrumL.果实；丁茄SolanumsurattenseBurm.f，有散瘀消肿，止痛拔毒的作用。生物活性
Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物，在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。体外研究
Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.
Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC
50
s are 9.21 and 19.88 μg/ml, respectively.
Cell Viability Assay
| Cell Line: | SMMC-7721cells |
| Concentration: | 15 μg/ml |
| Incubation Time: | 72 hours |
| Result: | Displayed a significant increase of sub-G1. |
体内研究
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo.
| Animal Model: | Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) |
| Dosage: | 10 mg/kg |
| Administration: | Intragastric administration; once daily for 8 days |
| Result: | Tumor growth was significantly inhibited . |