203849-91-6
中文名称
单甲基澳瑞他汀 D
英文名称
MonoMethyl Dolastatin 10
CAS
203849-91-6
分子式
C41H66N6O6S
分子量
771.06
MOL 文件
203849-91-6.mol
更新日期
2024/05/25 01:07:56
203849-91-6 结构式
基本信息
中文别名
一甲基澳瑞他汀 D单甲基澳瑞他汀 D
一甲基澳瑞他汀D/MMAD/
微管(TUBULIN)抑制剂(MMAD)
英文别名
MMADCS-1368
EOS-60620
DeMethyldolastatin 10
MonoMethylauristatin D
MonoMethyl Dolastatin 10
Demethyldolastatin (MMAD)
MMAD (Demethyldolastatin 10
DEMETHYLDOLASTATIN 10
MONOMETHYLAURISTATIN D
MONOMETHYL DOLASTATIN 10
N-Methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点906.1±65.0 °C(Predicted)
密度1.119±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度溶于二甲基亚砜
酸度系数(pKa)13.81±0.46(Predicted)
形态粉末
单甲基澳瑞他汀 D价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15581 | 单甲基澳瑞他汀 D MMAD | 203849-91-6 | 5mg | 800元 |
| 2024/04/30 | HY-15581 | 单甲基澳瑞他汀 D MMAD | 203849-91-6 | 10mg | 1400元 |
| 2024/04/30 | HY-15581 | 单甲基澳瑞他汀 D MMAD | 203849-91-6 | 50mg | 4500元 |
常见问题列表
生物活性
MMAD 是一种有效的微管 (tubulin) 抑制剂，是抗体药物偶联物 (ADCs) 中的活性分子。靶点
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Auristatin
|
体外研究
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity.
体内研究
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.