204205-90-3
中文名称
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
英文名称
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
CAS
204205-90-3
分子式
C22H16ClN3O2
分子量
389.83
MOL 文件
204205-90-3.mol
更新日期
2024/05/23 20:39:42
204205-90-3 结构式
基本信息
中文别名
2-溴-2-(2-氟苯基)-1-环丙乙酮2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
英文别名
ZIO 301Indibulin
Nascapine
lindiblin
2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-
2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
所属类别
医药中间体：苄基吡啶物理化学性质
密度1.31±0.1 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
酸度系数(pKa)9.38±0.70(Predicted)
形态固体
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 5mg | 700元 |
| 2024/04/30 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 10mM * 1mLin DMSO | 770元 |
| 2024/04/30 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 10mg | 1120元 |
常见问题列表
生物活性
Indibulin (ZIO 301, D 24851, Zybulin) 是一种口服的 tubulin assembly 抑制剂，并具有有效的抗癌活性。Indibulin 可诱导有丝分裂的停滞和凋亡。靶点
| Target | Value |
|
Tubulin
() |
体外研究
Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM.
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis.
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells.
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600, 900, 1200, 1500, 1800, 2100 nM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of MCF-7 cells with an IC 50 of 150 nM. |
Cell Cycle Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600 nM |
| Incubation Time: | 48 hours |
| Result: | Blocked the cells in the G2/M phase of the cell cycle. |
Apoptosis Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600 nM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in MCF-7 cells. |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600 nM |
| Incubation Time: | 48 hours |
| Result: | Generated cleaved fragments of PARP protein in 300 and 600 nM. |