20788-07-2
中文名称
雷琐太尔
英文名称
Resorantel
CAS
20788-07-2
分子式
C13H10BrNO3
分子量
308.13
MOL 文件
20788-07-2.mol
更新日期
2024/06/11 10:15:01
20788-07-2 结构式
基本信息
中文别名
雷琐太尔雷琐泰尔 标准品
N-(4-溴苯基)-2,6-二羟基苯甲酰胺
英文别名
RESORANTELPesorantelum
N-(4-Bromophenyl)-2,6-dihydroxybenzamide
Benzamide, N-(4-bromophenyl)-2,6-dihydroxy-
物理化学性质
熔点229-230°; mp 183-186° (LeMaire)
沸点391.1±42.0 °C(Predicted)
密度1.699±0.06 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度DMSO : 250 mg/mL (811.35 mM; Need ultrasonic)
酸度系数(pKa)7.62±0.35(Predicted)
常见问题列表
生物活性
Resorantel是一种安全的抗绦虫药，对莫尼茨绦虫和Thysaniezia spp.十分有效，对Paramphistomum spp.有一定效力。体内研究
Resorantel (65 mg/kg, a single oral dose) possesses efficacy against paramphistomiasis in naturally infected sheep.
| Animal Model: | Five flocks of sheep in different villages of Haryana. |
| Dosage: | 65 mg/kg. |
| Administration: | A single oral dose. |
| Result: | None of the treated sheep died of enteric paramphistomiasis. The clinical signs disappeared within 2 to 3 days of the treatment and their appetite and general condition improved. No ill effects of the drug were noticed. Of the untreated sheep, 35 % died with a range of 24-52 % in the different flocks. Many of the other untreated sheep continued to exhibit clinical signs of paramphistomiasis. |