2203-97-6
中文名称
氢化可的松琥珀酸酯
英文名称
Hydrocortisone 21-hemisuccinate
CAS
2203-97-6
分子式
C25H34O8
分子量
462.53
MOL 文件
2203-97-6.mol
更新日期
2024/05/22 15:14:04
2203-97-6 结构式
基本信息
中文别名
氢可琥珀酸酯琥珀酸氢化可的松
氢化可的松琥珀酸酯
羟基可的松琥珀酸酯
氢化可的松氢琥珀酸盐
氢化可的松半琥珀酸酯
氢化可的松半瑚珀酸酯
氢化可的松琥珀酸酯 1G
氢化可的松半琥珀酸酯无水
氢化可松琥珀氢 EP标准品
英文别名
C12888saxizon
NSC 7576
-2-oxoethoxy)
cortisolsuccinate
Hydrocortisone 21-he
CORTISOL HEMISUCCINATE
HYDROCORTISONE SUCCINATE
Hydrocortizone Succinate
CORTISOL 21-HEMISUCCINATE
所属类别
原料药：肾上腺皮质激素类药物理化学性质
熔点170～172℃
比旋光度[α]D20 +147～+153° (c=1, C2H5OH) (After Drying)
沸点685.5±55.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.
酸度系数(pKa)pKa 5.10/5.64(20% aq EtOH/50% aq EtOH) (Uncertain)
形态neat
颜色白色至灰白色
常见问题列表
用途
氢化可的松琥珀酸酯是一种皮质类固醇，用作分析和色谱试剂。
生物活性
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate)，一种糖皮质激素， 是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone hemisuccinate 可用于溃疡性结肠炎 (UC) 的研究。靶点
|
IL-6 6.7 μM (IC 50 ) |
IL-3 21.4 μM (IC 50 ) |
体外研究
Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC
50
s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
体内研究
Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.
| Animal Model: | Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis |
| Dosage: | 30 mg/kg |
| Administration: | P.o. twice daily for 5 days |
| Result: |
Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight. |