2975-36-2

中文名称哌卡嗪盐酸盐

英文名称 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride

CAS 2975-36-2

分子式 C19H23ClN2S

分子量 346.917

MOL 文件 2975-36-2.mol

更新日期 2023/03/20 15:41:25

2975-36-2 结构式

基本信息物理化学性质安全数据哌卡嗪盐酸盐价格(试剂级) 常见问题列表

基本信息

中文别名

哌卡嗪盐酸盐
甲哌啶嗪盐酸盐

英文别名

Mepazine hydrochloride
10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride

所属类别

有机原料：羧酸类化合物及衍生物

物理化学性质

储存条件-20°C储存

溶解度DMSO: 50 mg/mL (144.13 mM)

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302

防范说明P264-P270-P301+P312-P501

哌卡嗪盐酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-121282A	哌卡嗪盐酸盐 Mepazine hydrochloride	2975-36-2	25 mg	1150元
2024/04/30	HY-121282A	哌卡嗪盐酸盐 Mepazine hydrochloride	2975-36-2	50mg	1750元
2024/04/30	HY-121282A	哌卡嗪盐酸盐 Mepazine hydrochloride	2975-36-2	100mg	2550元

常见问题列表

生物活性

Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。

靶点

MALT1

体外研究

Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells.

Cell Viability Assay

Cell Line:	ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)
Concentration:	5, 10, and 20 μM
Incubation Time:	4 days
Result:	Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.

体内研究

Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg ^null (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10.

Animal Model:	6- to 8-week-old female NOD.Cg- Prkdc ^scid Il2rg ^tm1Wjl /SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model
Dosage:	400 μg per animal (25 g), corresponding to approximately 16 mg/kg
Administration:	Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
Result:	Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.