3106-85-2
中文名称
异冬谷酸
英文名称
N-acetyl aspartyl-glutaMic acid
CAS
3106-85-2
分子式
C11H16N2O8
分子量
304.25
MOL 文件
3106-85-2.mol
更新日期
2024/06/03 09:46:34
3106-85-2 结构式
基本信息
中文别名
异冬谷酸盐酸索他洛尔-D6
N-乙酰基-L-天冬氨酰-L-谷氨酸
英文别名
NAAGNAAGA
Naaxia
ZY-15106
AC-ASP-GLU
ALPHA-NAAG
ACETYL-D-E
AC-ASP-GLU-OH
AC-ASP-GLU H2O
SPAGLUMIC ACID
所属类别
生物化工：多肽物理化学性质
熔点171-173 °C
沸点769.5±60.0 °C(Predicted)
密度1.472±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度H2O: 50 mg/mL
溶解度H2O:50 mg/mL
酸度系数(pKa)3.04±0.10(Predicted)
形态powder
颜色white
旋光性 (optical activity)[α]22/D 34.5°, c = 1.1 in H2O(lit.)
水溶解性溶于水至100mM
稳定性吸湿性
常见问题列表
生物活性
Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一种在脑中以毫摩尔浓度存在的神经肽。靶点
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Human Endogenous Metabolite
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体外研究
Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca 2+ -dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.