321661-62-5
321661-62-5 结构式
基本信息
NUR77激动剂(CYTOSPORONE B)
Cytosporone B
Dothiorelone G
ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 2mg | 770元 |
| 2024/04/30 | S6674 | CSN-B Cytosporone B | 321661-62-5 | 5mg | 1040.99元 |
| 2024/04/30 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 5mg | 1100元 |
常见问题列表
| Target | Value |
|
Nur77
(Cell-free assay) | 0.278 nM(EC50) |
Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC 50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells.
In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min.