33401-94-4
中文名称
酒石酸噻吩嘧啶
英文名称
PYRANTEL TARTRATE SALT
CAS
33401-94-4
分子式
C15H20N2O6S
分子量
356.39
MOL 文件
33401-94-4.mol
更新日期
2023/09/08 15:48:11
33401-94-4 结构式
基本信息
中文别名
酒石酸噻嘧啶酒石酸噻吩嘧啶
英文别名
cp10423-18Pyrantel Tartate
PYRANTEL TARTRATE SALT
pyrantel hydrogen tartrate
PYRANTEL TARTRATE SALT ISO 9001：2015 REACH
(E)-4,5,6-TETRAHYDRO-1-METHYL-2-(2-(2-THIENYL)ETHENYL)PYRIMIDINE
(e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidinetartrate(1:
1-METHYL-2-[2-(2-THIENYL)ETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE TARTRATE SALT
(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine tartrate (1:1)
1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-pyrimidin(e)-pyrimidintartrate
所属类别
医药中间体：噻吩嘧啶物理化学性质
熔点148-150°
储存条件Inert atmosphere,Room Temperature
溶解度H2O中可溶 4.0ML，透明，无色至淡黄色或棕褐色（溶剂：200 mg 加 4.0 mL）
常见问题列表
生物活性
Pyrantel tartrate，一种四氢嘧啶光谱驱虫药，是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel tartrate 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel tartrate 可用于胃肠道线虫感染的研究。体外研究
Pyrantel induces
Ascaris suum
muscle contraction, with a pEC
50
of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of
Ancylostoma ceylanicum
,
Necator americanus
and
Trichuris muris
on the third-stage larvae (IC
50
s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC
50
s=>100, 7.6, and 34.1 µg/mL, respectively).
体内研究
Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.