35730-78-0

中文名称菜蓟苦素

英文名称 cynaropicrin

CAS 35730-78-0

分子式 C19H22O6

分子量 346.37

MOL 文件 35730-78-0.mol

更新日期 2024/05/13 10:59:09

35730-78-0 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

菜蓟苦素

英文别名

Cynaropikrin
cynaropicrin
CYNAROPICRIN(SH)
Cynaropicrin - Cynara cardunculus (artichoke)
2-Hydroxymethylpropenoic acid (3aR,4S,6aβ,9aβ,9bα)-dodecahydro-8α-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester
2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester
2-methylolacrylic acid [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-2-keto-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] ester
[(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate

所属类别

生物化工：植物提取物

物理化学性质

沸点566.2±50.0 °C(Predicted)

密度1.28±0.1 g/cm3 (20 ºC 760 Torr)

储存条件-20°C, protect from light

溶解度DMSO:50.0(Max Conc. mg/mL);144.35(Max Conc. mM)

酸度系数(pKa)13.52±0.10(Predicted)

LogP1.340 (est)

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H317

防范说明P261-P272-P280-P333+P313-P362+P364-P501

常见问题列表

生物活性

Cynaropicrin 是一种倍半萜内酯，可以抑制肿瘤坏死因子 (TNF-α) 的释放，在鼠和人巨噬细胞的 IC50 值分别为 8.24 和 3.18 μM。 Cynaropicrin 也抑制软骨降解因子 (MMP13) 的增加并抑制 NF-κB 的信号传导。

靶点

MMP13

NF-κB

TNF-α

体外研究

Cynaropicrin strongly inhibits lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC ₅₀ values of 8.24 and 3.18 μM, respectively. Cynaropicrin shows significant inhibitory effects toward all mitogenic signals with the IC ₅₀ values of 1.20 (concanavalin A), 1.02 (phytohemagglutinin) and 0.90 μM (lipopolysaccharide), respectively. Cynaropicrin suppresses CTLL-2 cell proliferation in a dose-dependent manner and the 50% inhibitory concentration (IC ₅₀ ) of Cynaropicrin for CTLL-2 cell growth is 0.91 μM. The increased mRNA expression of MMP13 induced by TNF-α is similarly inhibited in a concentration-dependent manner by Cynaropicrin. The increased mRNA expression of HIF-2α induced by IL-1β in SW1353 is inhibited in a concentration-dependent manner by Cynaropicrin.