36455-72-8

中文名称 ALPHA-玉米赤霉烯醇

英文名称 ALPHA-ZEARALENOL

CAS 36455-72-8

分子式 C18H24O5

分子量 320.38

MOL 文件 36455-72-8.mol

36455-72-8 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

玉米赤霉烯醇Α
Α-玉米赤霉烯醇
ALPHA-玉米赤霉烯醇
Α-玉米赤霉烯醇标准品
ALFA-ZEARALENOL
Α-玉米赤霉烯醇溶液,100PPM
Α-玉米赤霉烯醇溶液,1000PPM
乙腈中Α-玉米赤霉烯醇溶液,100ΜG/ML
2,4-二羟基- 6-(6Α,10-二羟基反式-)苯甲酸Μ-内酯
ALPHA-2,4二羟基- 6 - [10 -二羟基- 1 - 十一碳烯基]苯甲酸酯

英文别名

ZEARALENOL
Α-ZEARALENOL
A-ZEARALENOL
(3S,7R,11E)-
alfa-Zearalenol
ALPHA-ZEARALENOL
Zearalenol, alpha-
trans-α-Zearalenol
α-Zearalenol solution
alpha-Zearalenol solution

所属类别

分析化学：食品和化妆品标准品

物理化学性质

熔点158-161°C

沸点599.0±50.0 °C(Predicted)

密度1.174±0.06 g/cm3(Predicted)

闪点2℃

储存条件-20°C

溶解度≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide

酸度系数(pKa)7.61±0.60(Predicted)

形态结晶固体

稳定性吸湿性

安全数据

危险性符号(GHS)

GHS05,GHS08

警示词危险

危险性描述H314-H351-H361fd-H371-H412

防范说明P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

危险品标志Xn,T,F

危险类别码20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45

安全说明36/37-61-16-45-53

危险品运输编号UN 1648 3 / PGII

WGK Germany3

海关编码29322090

常见问题列表

生物活性

α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素, α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。

体外研究

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC ₅₀ of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.

Cell Proliferation Assay

Cell Line:	MFC-7 cells
Concentration:	6.25 µM-25 µM
Incubation Time:	24 hours
Result:	Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay

Cell Line:	Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration:	0.001 μM, 0.1 μM and 10 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis

Cell Line:	MCF7 cells, MDA-MB231 cells
Concentration:	0.001 μM, 0.1 μM and 10 μM
Incubation Time:	72 hours
Result:	Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR

Cell Line:	HepG2 cells
Concentration:	1 μM, 5 μM, 10 μM
Incubation Time:	72 hours
Result:	Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.