4004-05-1
中文名称
1,2-二油酰-SN-甘油-3-磷酰乙醇胺
英文名称
1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine
CAS
4004-05-1
分子式
C41H78NO8P
分子量
744.03
MOL 文件
4004-05-1.mol
更新日期
2024/05/25 16:55:54
4004-05-1 结构式
基本信息
中文别名
二油酰磷脂酰乙醇胺二油酰基磷脂酰乙醇胺
阳离子脂质体DOPE
SIRNA脂质体DOPE
二油酰磷脂酰乙醇胺DOPE
DOPE,二油酰磷脂酰乙醇胺
二油酰基 L-Α-磷脂酰乙醇胺
L-Α-磷脂酰乙醇胺,二油酰基
1,2-二油酰甘油-3-磷酸乙醇胺
二油酰磷脂酰乙醇胺DOPE-艾伟拓供
英文别名
DOPE18:1 PE
PE(18:1(9Z)/18:1(9Z))
COATSOME ME-8181 (DOPE)
L-β,γ-Dioleoyl-α-cephalin
18:1 (Delta9-Cis) PE (DOPE)
Dioleoyl phosphoethanolamine
1,2-Dioleoyl-sn-glycero-3-PE
DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
所属类别
生物：转染试剂物理化学性质
熔点200°C(lit.)
沸点759.2±70.0 °C(Predicted)
密度1.008±0.06 g/cm3(Predicted)
储存条件−20°C
储存条件-20°C
溶解度DMSO: 31.25 mg/mL (42.00 mM)
酸度系数(pKa)1.17±0.50(Predicted)
形态lyophilized powder
颜色白色至浅黄色
BRN1718431
InChIKeyMWRBNPKJOOWZPW-XFBMKQTANA-N
SMILES[C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r|
安全数据
1,2-二油酰-SN-甘油-3-磷酰乙醇胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | D4251 | 1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | 4004-05-1 | 250mg | 1000元 |
| 2024/04/30 | HY-112005 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | 4004-05-1 | 100mg | 1200元 |
| 2024/04/30 | HY-112005 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | 4004-05-1 | 250mg | 2450元 |
常见问题列表
生物活性
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。靶点
IC50: helper lipid for liposome
体外研究
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent).With the neutral lipid for the LNP is DOPE , LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity.LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs.