40456-50-6
中文名称
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
英文名称
(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one
CAS
40456-50-6
分子式
C22H24O7
分子量
400.42
MOL 文件
40456-50-6.mol
40456-50-6 结构式
基本信息
中文别名
亚太因(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
英文别名
YateinYatapoxvirusYatein
(+)-Deoxypodorhizon
(-)-Deoxypodorhizone
(-)-trans-3-(3,4-Methylenedioxybenzyl)-2-(3,4,5-trimethoxybenzyl)butyrolactone
(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one
(3S)-4,5-Dihydro-3β-(3,4,5-trimethoxybenzyl)-4α-(1,3-benzodioxol-5-ylmethyl)furan-2(3H)-one
(3S)-3β-(3,4,5-Trimethoxybenzyl)-4α-[(1,3-benzodioxole-5-yl)methyl]-4,5-dihydrofuran-2(3H)-one
所属类别
天然产物：木脂素常见问题列表
生物活性
Yatein 是从 A. chilensis 中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。靶点
HSV-1
体外研究
Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells.
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells.
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization.
Cell Viability Assay
| Cell Line: | A549 cells, CL1-5 cells |
| Concentration: | 1.25 μM , 2.5 μM , 5 μM |
| Incubation Time: | 24 hours |
| Result: | Induced cell-cycle arrest at G2/M phase in both cell lines. |
Cell Viability Assay
| Cell Line: | A549 cells, CL1-5 cells |
| Concentration: | 5 μM |
| Incubation Time: | 6 hours, 12 hours |
| Result: | Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation. |
体内研究
Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model.
| Animal Model: | Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection, five times per week, for 42 days |
| Result: | Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation. |