5119-48-2
5119-48-2 结构式
基本信息
醉茄素 A,来源于睡茄叶
WITHAFERIN A STANDARD
nsc-101088
Withaferine
WITHAFERIN A
withaferinea
Withaferin A Standard
Withaferin A 5119-48-2
delta-lactone,(20s,22r)-oxo
Withaferin A from leaves of Withania somnifera
5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-N2065 | 醉茄素 A Withaferin A | 5119-48-2 | 1mg | 1300元 |
| 2024/04/30 | S8587 | 醉茄素 A Withaferin A | 5119-48-2 | 1mg | 1470.11元 |
| 2024/04/30 | HY-N2065 | 醉茄素 A Withaferin A | 5119-48-2 | 5mg | 3900元 |
常见问题列表
| Target | Value |
|
NF-κB
() | |
|
vimentin
() |
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.