515-13-9
515-13-9 结构式
基本信息
Β-榄香烯
BETA-榄香烯
Β-榄香烯 标准品
Β-ELEMENE
β-Elemen
β-Elemene
(-)-beta-EL
beta-Elemene
β-ELEMENE82%
Levo-β-elemene
(-)-beta-Elemene
levo-beta-Elemene
β-Elemene (10mg/ml in ethanol)
物理化学性质
常见问题列表
β-Elemene (0-200 µg/ml; 24 hours) shows IC 50 values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively. β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml, induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase . β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells . β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway.
Cell Viability Assay
| Cell Line: | T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells |
| Concentration: | 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. |
Cell Cycle Analysis
| Cell Line: | T24 and 5637 cells |
| Concentration: | 0, 25, 50 and 75 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Induced the percentage of cells in the S-phase as a dose-dependent manner. |
Western Blot Analysis
| Cell Line: | T24 cells |
| Concentration: | 50 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Downregulated p-STAT3 and cell cycle-related proteins. |