535-83-1
基本信息
葫芦巴碱
烟酸甜菜碱
N-甲菸鹼酸內鹽
菸鹼酸N-甲內鹽
葫芦巴碱(标准品)
葫芦巴碱, 来源于葫芦巴
1-甲基吡啶-3-甲酸内盐
1-甲基吡啶鎓-3-甲酸内盐
TRIGONELLINE 葫芦巴碱
Gynesine
Coffearin
Coffearine
Caffearine
Trigonellin
Trigoneline
Trigenolline
TRIGONELLINE
betainnicotinate
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-N0414 | 葫芦巴碱 Trigonelline | 535-83-1 | 10mg | 700元 |
2024/04/30 | S3220 | 葫芦巴碱 Trigonelline | 535-83-1 | 5mg | 794.82元 |
2024/04/30 | HY-N0414 | 葫芦巴碱 Trigonelline | 535-83-1 | 50mg | 1600元 |
常见问题列表
Target | Value |
PLCγ1
() | |
PI3K
() | |
Akt
() | |
microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.