57432-61-8
中文名称
马来酸甲麦角新碱
英文名称
Methylergonovine maleate salt
CAS
57432-61-8
分子式
C24H29N3O6
分子量
455.5
MOL 文件
57432-61-8.mol
更新日期
2024/05/28 16:02:48
57432-61-8 结构式
基本信息
中文别名
马来酸甲麦角新碱马来酸甲基麦角新碱
顺丁烯二酸甲基新麦角碱
英文别名
ErezinDerganin
Partan M
erezingen
Metenarin
Methergin
methergine
Ryegonovin
Basofortina
Spametrin F
所属类别
原料药：垂体激素类药物理化学性质
熔点1720C (dec)
沸点561.98°C (rough estimate)
密度1.2744 (rough estimate)
折射率1.6500 (estimate)
储存条件-20°C冷冻
溶解度H2O: 25 mg/mL
溶解度在水中的溶解度25 mg/mL
形态neat
颜色white
水溶解性Soluble to 25 mM in water
安全数据
警示词危险
危险性描述H301+H311+H331-H361
危险品标志T
危险类别码23/24/25-62
安全说明36/37/39-45
危险品运输编号UN 1544 6.1/PG 3
危险品运输编号UN 1544 6.1/PG 3
WGK Germany3
WGK Germany3
RTECS号KE5500000
危险等级6.1(b)
包装类别III
海关编码2939690000
马来酸甲麦角新碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-100988 | 马来酸甲麦角新碱 Methylergometrine maleate | 57432-61-8 | 10mM * 1mLin DMSO | 1430元 |
| 2024/01/25 | HY-100988 | 马来酸甲麦角新碱 Methylergometrine maleate | 57432-61-8 | 5mg | 1300元 |
| 2024/01/25 | HY-100988 | 马来酸甲麦角新碱 Methylergometrine maleate | 57432-61-8 | 10mg | 2300元 |
常见问题列表
生物活性
Methylergometrine maleate (Methylergonovine maleate) 是一种麦角生物碱，是一种具有血管收缩和子宫收缩作用的 Methysergide 的活性代谢产物。Methylergometrine maleate 是一种有效的，选择性的，具有口服活性的 5-HT 受体拮抗剂，pA2 值为 9.6。Methylergometrine maleate 具有抗偏头痛和多巴胺能活性，可用于预防和控制产后出血。靶点
|
serotonin 9.6 nM (pA2) |
体外研究
Both Methysergide and Methylergometrine displace the concentration-response curve of 5-HT to the right and depressed the maximum effect ; thus, both agents behaved as non-competitive antagonists of 5-HT. Methylergometrine is approximately 40-times more potent than Methysergide as an antagonist of the 5-HT-induced responses, since the calculated apparent pA2 values are 9.6 and 8.0, respectively.
体内研究
Methylergometrine is more potent than Methysergide as a vasoconstrictor on bovine middle cerebral artery and human coronary arteries, an effect on 5-HT1B receptors. Subacute oral administration would result in metabolism of Methysergide to Methylergometrine.