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5874-97-5

中文名称 硫酸奥西那林
英文名称 Orciprenaline sulfate
CAS 5874-97-5
分子式 C22H36N2O10S
分子量 520.59
MOL 文件 5874-97-5.mol
更新日期 2023/03/20 15:41:21
5874-97-5 结构式 5874-97-5 结构式

基本信息

中文别名
硫酸异丙喘宁
硫酸奥西那林
硫酸奥昔帕林
异丙喘宁硫酸盐
奥西那林硫酸盐
硫酸奥肾上腺素
奥西那林半硫酸盐
硫酸奥西那林 标准品
硫酸奥西那林(异丙喘宁)
奥西那林半硫酸盐 标准品
英文别名
alotec
th-152
alupent
metaprel
Astmopent
novasmasol
ORCIPRENALINE SULFATE
METAPROTERENOL SULFATE
dl-Orciprenaline sulfate
METAPROTERENOLSULFATE,USP
所属类别
原料药:平喘药

物理化学性质

熔点202-203°
储存条件2-8°C
溶解度Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
形态neat
颜色白色至灰白色
稳定性吸湿性

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H332
危险品标志Xn
危险类别码20
安全说明36
WGK Germany2
RTECS号DO2275000
海关编码2922504500
毒性LD50 in rats (mg/kg): 42 orally (Goldenthal)
硫酸奥西那林价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-B1276硫酸奥西那林
Metaproterenol hemisulfate
5874-97-550mg500元
2024/04/30HY-B1276硫酸奥西那林
Metaproterenol hemisulfate
5874-97-510mM * 1mLin DMSO550元
2024/04/30HY-B1276硫酸奥西那林
Metaproterenol hemisulfate
5874-97-5100mg700元

常见问题列表

生物活性
Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药,是 β2-肾上腺素能受体 (β2AR) 激动剂,其 IC50 为 68 nM。Metaproterenol hemisulfate 还具有抗炎活性。
靶点

IC50: 68 nM (β2-adrenergic receptor)

体外研究

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.

Western Blot Analysis

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Led to downregulation of NF-κB.
体内研究

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

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