633-35-2
中文名称
雄甾-1,4,6-三烯-3,17-二酮
英文名称
ANDROSTA-1,4,6-TRIENE-3,17-DIONE
CAS
633-35-2
分子式
C19H22O2
分子量
282.38
MOL 文件
633-35-2.mol
633-35-2 结构式
基本信息
中文别名
雄甾-1,4,6-三烯-3,17-二酮ATD (1,4,6三烯-雄甾-3,17-二酮)
英文别名
Δ1,4,6-androgen1,4,6-Andorstatriene-3,17-dione
androsta-1,4,6-triene-3,17-dione
1,4,6-Androstatriene-3,17-dione(ATD)
Androsta-1,4,6-triene-3,17-dione (1.0mg/mL in MeOH)
物理化学性质
熔点164-1650C
沸点452.8±45.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度methanol: 50 mg/mL, soluble
形态powder
常见问题列表
生物活性
Androsta-1,4,6-triene-3,17-dione 是亲脂性、特异性的芳香酶 (aromatase) 抑制剂，Ki 值为 0.18 μM。Androsta-1,4,6-triene-3,17-dione 可抑制雌激素生物合成，具有避孕作用。Androsta-1,4,6-triene-3,17-dione 能诱导空间记忆障碍。靶点
Ki: 0.18 μM (aromatase)
体内研究
Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations.
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis .
| Animal Model: | Rats (220-250 g) |
| Dosage: | 25 mg/kg, 100 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus. |