636-58-8
中文名称
G-谷氨酸-半胱-三氟乙酸盐
英文名称
GAMMA-GLU-CYS TRIFLUOROACETATE SALT
CAS
636-58-8
分子式
C8H14N2O5S
分子量
250.27
MOL 文件
636-58-8.mol
更新日期
2024/05/29 11:09:47
636-58-8 结构式
基本信息
中文别名
谷胱甘肽杂质D谷胱甘肽EP杂质D
Γ-GLU-半胱氨酸
Γ-谷氨酸-半胱氨酸
Γ-谷氨酰-半胱氨酸
谷胱甘肽杂质D(EP)
Γ-L-谷氨酰基-L半胱氨酸
L-Γ-谷氨酰-L-半胱氨酸
G-谷氨酸-半胱-三氟乙酸盐
5-L-谷氨酰-L-半胱氨酸
英文别名
γ-glu-cysy-Glu-Cys
gaMMa-Glu-Cys
H-g-Glu-Cys-OH
Gamma Glu-L-Cys-OH
H-GLU(CYS-OH)-OH TFA
gamma-glutamylcysteine
γ-L-Glutamyl-L-cysteine
5-L-Glutamyl-L-cysteine
Glutathione Ep Impurity D
所属类别
生物化工：谷氨酸类衍生物物理化学性质
熔点167℃
沸点592.4±50.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度≥ 25mg/mL in Water, ≥ 52 mg/mL in DMSO, ≥ 54.8 mg/mL in EtOH
酸度系数(pKa)2.21±0.10(Predicted)
InChIKeyRITKHVBHSGLULN-WHFBIAKZSA-N
常见问题列表
生物活性
Gamma-glutamylcysteine (γ-Glutamylcysteine) 是一种含有半胱氨酸和谷氨酸的二肽，是谷胱甘肽 (GSH) 的前体。Gamma-glutamylcysteine 是谷胱甘肽过氧化物酶 (GPx) 增加 GSH 水平的辅助因子。靶点
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Human Endogenous Metabolite
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体外研究
Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.