656820-32-5
中文名称
REVERSINE
英文名称
REVERSINE
CAS
656820-32-5
分子式
C21H27N7O
分子量
393.49
MOL 文件
656820-32-5.mol
更新日期
2024/05/25 01:23:32
656820-32-5 结构式
基本信息
中文别名
逆转素逆转素, >96%
AURORA激酶抑制剂(REVERSINE)
N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
英文别名
CS-870REVERSINE
Reversine, >96%
Reversine, >=98%
REVERSINE USP/EP/BP
Picropodophyllin (PPP)
2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE
N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE
N6-Cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine
N6-CYCLOHEXYL-N2-[4-(4-MORPHOLINYL)PHENYL]-1H-PURINE-2,6-DIAMINE
所属类别
生物化工：蛋白酪氨酸激酶物理化学性质
熔点305℃ (decomposition)
沸点736.4±70.0 °C(Predicted)
密度1.343±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: 7 mg/mL, soluble
酸度系数(pKa)10.51±0.10(Predicted)
形态solid
颜色米白色
稳定性从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 3 个月
常见问题列表
生物活性
Reversine是一种强效human A3 adenosine receptor拮抗剂，Ki为0.66 μM，也是一种泛aurora A/B/C kinase抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞分化。体外研究
Reversine induces myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, which proliferates and redifferentiates into bone and fat cells. Reversine, as an A3 adenosine receptor antagonist, competitively inhibits forskolin-stimulated cAMP production in stably transfected Chinese hamster ovary (CHO) cells. Reversine inhibits the phosphorylation of a well-known Aurora target, histone H3 in HCT116 cells. Moreover, Reversine potently blocks proliferation of multiple tumor cell types, and induces cell death. In primary human tumor samples, Reversine also inhibits colony formation of leukemic cells. When treated in combination, reversine and aspirin synergistically inhibit growth of cervical cancer cells and induce cell apoptosis.体内研究
In mice inoculated with U14 tumors, Reversine (10 mg/kg i.p.) and aspirin cause more reduced tumor weight and tumor volume when compared with the control agents.