74805-92-8
中文名称
麦冬高异黄酮A
英文名称
Methylophiopogonanone A
CAS
74805-92-8
分子式
C19H18O6
分子量
342.34
MOL 文件
74805-92-8.mol
更新日期
2024/05/27 17:09:25
74805-92-8 结构式
基本信息
中文别名
麦冬高异黄酮A麦冬甲基黄烷酮A
甲基麦冬黄烷酮A
甲基麦冬二氢高异黄酮A
麦冬高异黄酮A,甲基麦冬黄烷酮A
甲基麦冬二氢高异黄酮A(麦冬高异黄酮A
甲基麦冬二氢高异黄酮A,甲基麦冬黄烷酮A
甲基麦冬二氢高异黄酮A(麦冬高异黄酮A,甲基麦冬黄烷酮A)
英文别名
Methylophiopogonanone AR-Methylophiopogonanone A
8-Methylophiopogonanone A
Methylophiopogonanone A (MO-A)
Methylophiopogonanone A(R-Methylophiopogonanone A)
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-
所属类别
天然产物：黄酮类化合物物理化学性质
外观性状可溶于甲醇、乙醇、DMSO等有机溶剂，来源于麦冬须根Ophiopogon japonicus．。
沸点580.1±50.0 °C(Predicted)
密度1.410
溶解度Soluble in chloroform and methanol;
酸度系数(pKa)8.24±0.40(Predicted)
形态粉末
颜色淡黄色
水溶解性不溶于水
常见问题列表
生物活性
Methylophiopogonanone A 是从 Ophiopogon japonicas 提取到的黄酮类化合物，具有抗氧化和抗炎作用。体外研究
Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).
体内研究
Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.