76-78-8

中文名称苦木素

英文名称 QUASSIN

CAS 76-78-8

分子式 C22H28O6

分子量 388.45

MOL 文件 76-78-8.mol

更新日期 2024/05/21 17:08:56

76-78-8 结构式

基本信息物理化学性质安全数据应用领域苦木素价格(试剂级) 常见问题列表

基本信息

中文别名

苦味素
苦木素
QUASSIN (~90%)
QUASSIN (>
95%)

英文别名

Balsam
QUASSIN
Nsc 36342
Alloquassin
4-epiquassin
Quassin (>
QUASSINPOWDER
Quassin (~90%)
Quassin (>95%)
Einecs 200-985-9

所属类别

天然产物：萜类

物理化学性质

熔点222°

比旋光度D20 +34.5° (c = 5.09 in CHCl3)

沸点586.3±50.0 °C(Predicted)

密度1.23±0.1 g/cm3(Predicted)

储存条件-20°C Freezer, Under inert atmosphere

溶解度可溶于氯仿（少许）、甲醇（少许）

形态固体

颜色白色至灰白色

LogP2.220 (est)

EPA化学物质信息Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8)

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H332-H319-H312

防范说明P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P

应用领域

用途1

Quassin is a naturally occurring extract from quassia trees and is used in traditional chinese medicine for it鈥檚 antiulcerogenic properties. Quassin have also been used as an additive in soft drinks.

苦木素价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-N1581	苦木素 Quassin	76-78-8	1mg	900元
2024/04/30	HY-N1581	苦木素 Quassin	76-78-8	5mg	3600元
2023/03/20	HY-N1581	苦木素 Quassin	76-78-8	10mg	9800元

常见问题列表

生物活性

Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力，抗雌激素和抗疟原虫活性。

靶点

IC50: 0.15 μM ( P. falciparum )

体外研究

Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.

体内研究

Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.

Animal Model:	35 females albino rats (150-170 g)
Dosage:	0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg
Administration:	Oral administration; daily; for 60 days
Result:	There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.