775351-88-7
中文名称
3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮
英文名称
3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
CAS
775351-88-7
分子式
C25H26O4
分子量
390.47
MOL 文件
775351-88-7.mol
更新日期
2024/02/02 15:50:10
775351-88-7 结构式
基本信息
中文别名
次苷酸查尔酮次甘酸查耳酮
补骨脂异黄酮A
化合物CORYLIFOL A
CORYLIFOL A(标准品)
6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮
3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮
英文别名
CorylininCorylifol A
7-Dimethyl-2
3-[3-[(2E)-3
Corylifol A, >99%
CORYLIFOL ACORYLIFOL A
3'-Geranyl-4',7-dihydroxyisoflavone
CORYLIFOL A
3'-GERANYL-4',7-DIHYDROXYISOFLAVONE
CORYLININ
6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
所属类别
天然产物：黄酮类化合物物理化学性质
沸点609.3±55.0 °C(Predicted)
密度1.191
储存条件-20°C储存
溶解度DMF:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);64.02(Max Conc. mM)
酸度系数(pKa)6.92±0.20(Predicted)
形态粉末
颜色偏黄色
常见问题列表
生物活性
Corylifol A 能够抑制IL-6 诱导的 STAT3 的激活和磷酸化，其IC50 值为0.81 μM。靶点
|
STAT3 0.81 μM (IC 50 ) |
体外研究
Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μM. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K i values ranging from 0.62 μM to 3.89 μM.