80288-49-9
中文名称
呋喃茶碱
英文名称
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
CAS
80288-49-9
分子式
C12H12N4O3
分子量
260.25
MOL 文件
80288-49-9.mol
更新日期
2024/05/22 13:59:51
80288-49-9 结构式
基本信息
中文别名
呋拉茶碱呋喃菲林
呋喃茶碱
英文别名
FURAFYLLINEFURAFYLLINE INHIBITOR OF CYTOCHRO
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-
Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione
所属类别
有机原料：杂环化合物物理化学性质
熔点>162°C (dec.)
沸点543.6±60.0 °C(Predicted)
密度1.443±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度ethanol: 0.33 mg/mL
酸度系数(pKa)8.62±0.70(Predicted)
形态solid
颜色white
InChIKeyKGQZGCIVHYLPBH-UHFFFAOYSA-N
常见问题列表
生物活性
Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂，其 IC50 值为 0.07 μM。靶点
IC50: 0.07 μM (human cytochrome P450IA2)
体内研究
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.