849214-04-6
中文名称
C-GPAP
英文名称
c-GpAp
CAS
849214-04-6
分子式
C20H24N10O13P2
分子量
674.41
MOL 文件
849214-04-6.mol
更新日期
2024/06/05 14:00:08
849214-04-6 结构式
基本信息
中文别名
CGAMP铵盐CGAMP 钠盐
英文别名
cGAMPc-GpAp
di-GAMP
di-cGAMP
3'3'-cGAMP
Cyclic GMP-AMP
cGAMP ammonium salt
cGAMP (Cyclic GMP-AMP
c-(ApGp) / 3'3'-cGAMP
RFCBNSCSPXMEBK-XRIIRFCZSA-N
所属类别
生物化工：抑制剂物理化学性质
沸点1159.9±75.0 °C(Predicted)
密度2.61±0.1 g/cm3(Predicted)
储存条件-20°C
酸度系数(pKa)0.96±0.70(Predicted)
形态粉末
颜色白色至米色
水溶解性Water : 20 mg/mL (29.66 mM)
常见问题列表
生物活性
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ，从而诱导抗病毒状态和I型IFN的分泌。靶点
| Target | Value |
|
STING
() |
体外研究
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
体内研究
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old |
| Dosage: | 5 µg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |