934369-14-9
中文名称
934369-14-9
英文名称
TY-52156
CAS
934369-14-9
分子式
C18H19Cl2N3O
分子量
364.27
MOL 文件
934369-14-9.mol
更新日期
2024/06/11 08:37:31
934369-14-9 结构式
基本信息
中文别名
化合物TY-52156 英文别名
TY-52156TY52156
TY 52156
N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine
N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine
N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Butanimidic acid, N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-, 2-(4-chlorophenyl)hydrazide
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点90-91 °C
沸点62-69 °C(Press: 20 Torr)
密度1.22±0.1 g/cm3(Predicted)
储存条件2-8°C(protect from light)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度≥92.8 mg/mL in DMSO; ≥94.6 mg/mL in EtOH; insoluble in H2O
酸度系数(pKa)0.99±0.50(Predicted)
形态结晶固体
934369-14-9价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-19736 | 934369-14-9 TY-52156 | 934369-14-9 | 5mg | 700元 |
| 2024/04/30 | HY-19736 | 934369-14-9 TY-52156 | 934369-14-9 | 10mg | 1100元 |
| 2024/04/30 | HY-19736 | 934369-14-9 TY-52156 | 934369-14-9 | 50mg | 3800元 |
常见问题列表
生物活性
TY-52156 是一种有效、选择性的 S1P3 受体拮抗剂，Ki 值为 110 nM。靶点
Ki: 110 nM (S1P 3 )
体外研究
TY-52156 inhibits the S1P
3
receptor-dependent increase in [Ca
2+
]
i
.
TY-52156 shows submicromolar potency and a high degree of selectivity for S1P
3
receptor.
TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.
Western Blot Analysis
| Cell Line: | Chinese hamster ovary K1 cells |
| Concentration: | 10 μM |
| Incubation Time: | 10 min |
| Result: | Inhibited S1P-induced p44/p42 MAPK phosphorylation. |
体内研究
TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P
3
receptor-induced bradycardia after oral administration in vivo.
| Animal Model: | Male SD rats (290–340 g) |
| Dosage: | 10 mg/kg, 30 mg/kg |
| Administration: | Oral administration |
| Result: | Inhibited S1P 3 receptor-induced bradycardia after oral administration in vivo. |