950455-15-9
中文名称
利普司他丁-1
英文名称
Liproxstatin-1
CAS
950455-15-9
分子式
C19H21ClN4
分子量
340.85
MOL 文件
950455-15-9.mol
更新日期
2024/05/20 09:30:14
950455-15-9 结构式
基本信息
中文别名
N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺 英文别名
CS-1656Liproxstatin-1
Liproxstatin-1 USP/EP/BP
LIPROXSTATIN-1
LIPROXSTATIN1
N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine
N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine
N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
所属类别
生物化工：Ferroptosis 抑制剂
常见问题列表
生物活性
Liproxstatin-1 是一种有效的 ferroptosis 抑制剂。体外研究
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).体内研究
Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.生物活性
Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。靶点
| Target | Value |
|
ferroptosis
(Cell-free assay) | 22 nM |
体外研究
Liproxstatin-1能够在低纳摩尔范围内抑制铁死亡和Gpx4
体内研究
与溶剂对照组相比，Liproxstatin-1可显著地延长生存期，抑制管状细胞中铁死亡，减轻缺血/再灌注诱发的肝损伤中的组织损伤。