99217-63-7
中文名称
苦参新醇 A
英文名称
Leachianone E
CAS
99217-63-7
分子式
C25H28O5
分子量
408.49
MOL 文件
99217-63-7.mol
更新日期
2024/03/04 17:20:48
99217-63-7 结构式
基本信息
中文别名
苦参醇A苦参新醇 A
苦参新醇A对照品
苦参新醇A标准品
英文别名
Kushenol ALeachianone E
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
所属类别
天然产物:黄酮类化合物物理化学性质
熔点175-178 °C
沸点581.7±50.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
储存条件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)7.66±0.40(Predicted)
形态Cryst.
常见问题列表
生物活性
Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂,可阻止 L-tyrosinase 转化为 L-DOPA,IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂,对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。靶点
IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)
体外研究
Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells.
Cell Viability Assay
Cell Line: | NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B |
Concentration: | 0-60 μg/ml |
Incubation Time: | 24 hours |
Result: | Exhibited considerable cytotoxic effects against NSCLC cells. |