1KG | 备注:厂家优势供应
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- CAS号:
- 180300-43-0
- 英文名:
- 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine
- 英文别名:
- ECyd;TAS 106;ETHYNYCYTIDINE;Ethynylcytidine;3'-Ethynylcytidine;3'-C-Ethynylcytidine;Ethynylcytidine(ECyD);3’-β-C-Ethynylcytidine;cytidine, 3'-c-ethynyl-;3'-beta-C-Ethynylcytidine
- 中文名:
- 1KG | 备注:厂家优势供应
- 中文别名:
- 化合物ETHYNYLCYTIDINE;ECYD|||3'-C-ETHYNYLCYTIDINE|||TAS-106
- CBNumber:
- CB02490124
- 分子式:
- C11H13N3O5
- 分子量:
- 267.24
- MOL File:
- 180300-43-0.mol
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1KG | 备注:厂家优势供应化学性质
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熔点:
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233-235 °C
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沸点:
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536.4±60.0 °C(Predicted)
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密度:
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1.61±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:127.5(Max Conc. mg/mL);477.1(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);18.71(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.42(Max Conc. mM)-
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形态:
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A solid
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酸度系数(pKa):
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11.54±0.70(Predicted)
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1KG | 备注:厂家优势供应性质、用途与生产工艺
Ethynylcytidine (ECyD) 是一种核苷类似物，是 RNA 合成 (RNA synthesis) 的有效抑制剂，可抑制 RNA 聚合酶 I，II 和 II。Ethynylcytidine 在多种癌症模型中均具有强大的抗肿瘤活性。
nucleoside antimetabolite
The IC
50
values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. These results suggest that the cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The differences in IC
50
values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appeares to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors. Even at the 4 h exposure time, Ethynylcytidine clearly shows potent cytotoxicity with IC
50
values at submicromolar concentrations in 4 of the 5 human tumors.
In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with an tumor growth inhibition rate (IR) on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine (TAS-106) on all three administration schedules. In particular, administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.
1KG | 备注:厂家优势供应
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16200 | 1KG | 备注:厂家优势供应
Ethynylcytidine | 180300-43-0 | 5mg | 1400元 |
| 2024/04/30 | HY-16200 | 1KG | 备注:厂家优势供应
Ethynylcytidine | 180300-43-0 | 10mM * 1mLin DMSO | 1540元 |
180300-43-0, 1KG | 备注:厂家优势供应 相关搜索:
- Nucleosides
- ECYD|||3'-C-ETHYNYLCYTIDINE|||TAS-106
- 化合物ETHYNYLCYTIDINE
- 180300-43-0
- 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine
- Ethynylcytidine(ECyD)
- 1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE
- Ethynylcytidine (TAS-106)
- 3'-beta-C-Ethynylcytidine
- 3'-Ethynylcytidine
- 3'-C-Ethynylcytidine
- ECYD;TAS-106;3'-C-ETHYNYLCYTIDINE
- 3’-beta-C-Ethynylcytidine, ECYD, TAS-106
- 3’-β-C-Ethynylcytidine
- cytidine, 3'-c-ethynyl-
- 4-Amino-1-((2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
- Ethynylcytidine
- TAS 106
- ECyd
- ETHYNYCYTIDINE
- 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine