216691-95-1
|
|
|
- CAS号:
- 216691-95-1
- 英文名:
- 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- 英文别名:
- BZ48;Bz-423;Bz 423 (BZ48);Bz-423 >=98% (HPLC);7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)-
- 中文名:
- 216691-95-1
- 中文别名:
- 化合物 T14846
- CBNumber:
- CB02520450
- 分子式:
- C27H21ClN2O2
- 分子量:
- 440.92
- MOL File:
- 216691-95-1.mol
|
|
|
216691-95-1化学性质
-
沸点:
-
697.2±55.0 °C(Predicted)
-
|
-
密度:
-
1.28±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : ≥ 125 mg/mL (283.50 mM)
-
|
-
酸度系数(pKa):
-
9.05±0.30(Predicted)
-
|
216691-95-1性质、用途与生产工艺
Bz 423 是一种促凋亡的1,4-苯并二氮平类化合物，能够活化 Bax 和 Bak，能用于红斑狼疮等自身免疫病的研究。
Bz-423 induces a larger superoxide response in Ramos cells, and causes rapid death of Ramos B cells. Bz-423 activates Bax and Bak, but does not activate ASK1/JNK in Ramos cells. In Ramos cells Bz-423-induced superoxide leads to Bax and Bak activation via changes in Mcl-1 expression and functional activation of BH3-only proteins. Bz-423 rapidly increases superoxide levels in MEFs within 1 h and the magnitude of the increase is concentration-dependent. Bz-423-induced apoptosis dependents upon superoxide.
216691-95-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13108 | 216691-95-1
Bz 423 | 216691-95-1 | 5mg | 950元 |
| 2024/04/30 | HY-13108 | 216691-95-1
Bz 423 | 216691-95-1 | 10mM * 1mLin DMSO | 1050元 |
216691-95-1, 216691-95-1 相关搜索:
- 抑制剂
- 化合物 T14846
- 216691-95-1
- Bz 423 (BZ48)
- Bz-423 >=98% (HPLC)
- BZ48
- 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)-
- Bz-423
- 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one