3-Α-氨基胆甾烷(3AC)
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- CAS号:
- 2206-20-4
- 英文名:
- Cholestan-3-aMine, (3α,5α)-
- 英文别名:
- 3α-Aminocholestane;3α-Aminocholestane;3alpha-Aminocholestane;3Α-AMINOCHOLESTANE (3AC);(3α,5α)-Cholestan-3-amine;(3α,5α)-Cholestan-3-amine;3-a-aMinocholestane (3AC);Cholestan-3-aMine, (3α,5α)-;5alpha-Cholestan-3alpha-amine;3αAminocholestane,3α Aminocholestane
- 中文名:
- 3-Α-氨基胆甾烷(3AC)
- 中文别名:
- 3Α-氨基胆甾烷;3Α-氨基胆甾烷;化合物 T14037;3-Α-氨基胆甾烷(3AC);3伪-AMINOCHOLESTANE;5ALPHA-胆甾烷-3ALPHA-胺;SHIP1抑制剂(3Α-AMINOCHOLESTANE)
- CBNumber:
- CB02595032
- 分子式:
- C27H49N
- 分子量:
- 387.68
- MOL File:
- 2206-20-4.mol
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3-Α-氨基胆甾烷(3AC)化学性质
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熔点:
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104.5-105.5℃ (methanol )
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沸点:
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160 °C(Press: 0.1 Torr)
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密度:
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0.930±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Chloroform: 30 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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10.94±0.70(Predicted)
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3-Α-氨基胆甾烷(3AC)性质、用途与生产工艺
3α-Aminocholestane 是含有选择性 SH2 结构域的肌醇-5'-磷酸酶 1 (SHIP1) 的抑制剂，其 IC50 值约为 2.5 μM。
OPM2 cell viability is effectively reduced by 3α-Aminocholestane (3AC) treatment. RPMI8226 and U266 cells show significantly less sensitivity to 3α-Aminocholestane treatment when compare with OPM2 cells, although viability is decreased significantly at concentrations of ≥12.5 μM. Treatment with 3α-Aminocholestane for 36 h severely reduces the percentage of cells in the S phase, which is accompanied by an increase of cells in the G2/M phase. In contrast, in the less proliferative RPMI8226 and U266 cells, cell cycle progression is blocked in the G0/G1 phase upon 3α-Aminocholestane treatment, in conjunction with a reduced percentage of cells undergoing the S phase.
It is found that 3α-Aminocholestane (3AC) results in reduced multiple myeloma (MM) growth
in vivo
, as determined by quantitation of free human Igλ light chain in the plasma after OPM2 challenge. In addition, reduced numbers of circulating OPM2 cells, as determined by human HLA-ABC staining, is observed in peripheral blood from 3α-Aminocholestane-treated mice compare with vehicle controls. Most importantly, 3α-Aminocholestane treatment results in significantly enhanced survival of mice after tumor challenge. In 3α-Aminocholestane-treated mice that resist treatment, it is found that MM tumors exhibit an upregulation of SHIP2, reminiscent of
in vitro
treatment of OPM2 cells and suggesting that SHIP1 inhibition may select for tumor cells with increased SHIP2 expression.
3-Α-氨基胆甾烷(3AC)
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-19776 | 3-Α-氨基胆甾烷(3AC)
3α-Aminocholestane | 2206-20-4 | 10mM * 1mLin Ethanol | 938元 |
| 2024/04/30 | HY-19776 | 3-Α-氨基胆甾烷(3AC)
3α-Aminocholestane | 2206-20-4 | 5mg | 1100元 |
2206-20-4, 3-Α-氨基胆甾烷(3AC) 相关搜索:
- 制剂-抑制剂
- 细胞生物学试剂
- C27H49N
- 3Α-氨基胆甾烷
- 化合物 T14037
- SHIP1抑制剂(3Α-AMINOCHOLESTANE)
- 3伪-AMINOCHOLESTANE
- 3Α-氨基胆甾烷
- 5ALPHA-胆甾烷-3ALPHA-胺
- 3-Α-氨基胆甾烷(3AC)
- 2206-20-4
- 3αAminocholestane,3α Aminocholestane
- 3α-Aminocholestane
- 3Α-AMINOCHOLESTANE (3AC)
- (3α,5α)-Cholestan-3-amine
- (3α,5α)-Cholestan-3-amine
- 3α-Aminocholestane
- 3-a-aMinocholestane (3AC)
- Cholestan-3-aMine, (3α,5α)-
- 5alpha-Cholestan-3alpha-amine
- 3alpha-Aminocholestane