4-羟基壬烯醛
|
|
|
- CAS号:
- 75899-68-2
- 英文名:
- HNE
- 英文别名:
- 4-HNE;4-HYDROXYNONENAL;4-HYDROXY-2-NONENAL;(E)-4-hydroxynon-2-enal;HNE;Ccris 1781;4-hydroxy-2-nonena;(E)-4-HYDROXYNONENAL;HNE ISO 9001：2015 REACH;(+/-)-4-HYDROXYNON-2-ENAL
- 中文名:
- 4-羟基壬烯醛
- 中文别名:
- 4-羟基壬醛;4-羟基壬烯醛;4-羟基壬烯醛抗体;干冰运输]4-羟基壬烯醛;反式-4-羟基-2-壬烯醛;(E)-4-羟基-2-壬烯醛;PE标记的4-羟基壬烯醛抗体;AF647标记的4-羟基壬烯醛抗体;鱼4-羟基壬烯酸(4-HNE)ELISA试剂盒;ANTI-4 HYDROXYNONENAL ANTIBODY-4-羟基壬烯醛抗体
- CBNumber:
- CB0281140
- 分子式:
- C9H16O2
- 分子量:
- 156.22
- MOL File:
- 75899-68-2.mol
|
|
|
4-羟基壬烯醛化学性质
-
沸点:
-
125-127 °C(Press: 2 Torr)
-
|
-
密度:
-
0.941±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
-70°C
-
|
-
溶解度:
-
DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
-
|
-
酸度系数(pKa):
-
13.31±0.20(Predicted)
-
|
-
形态:
-
Colorless oil.
-
|
-
CAS 数据库:
-
75899-68-2(CAS DataBase Reference)
-
|
4-羟基壬烯醛性质、用途与生产工艺
4-Hydroxynonenal (4-HNE) 是一种 α，β 不饱和羟基烯醛，是一种氧化/亚硝化应激生物标志物。4-Hydroxynonenalal 是 ALDH2 的底物和抑制剂。4-Hydroxynonenalal 可以调节许多信号传导过程，主要是通过与蛋白质，核酸和膜脂质中具有亲核官能团的共价加合物形成的。4-Hydroxynonenalal 通过线粒体在癌症中起重要作用。
|
Human Endogenous Metabolite
|
4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and become irreversible when the concentration of 4-HNE reaches 10 µM.
4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress.
4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C > A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA. A classic example of etiological relevance of 4-Hydroxynonenal-dG in human cancers is 4-Hydroxynonenal-dG induced p53 mutation. 4-Hydroxynonenal-dG adducts were preferentially formed at the third base of codon 249 in the p53 gene, causing gene mutation and affecting diverse biological processes including cell cycle arrest, apoptosis, DNA repair, and differentiation.
Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2
+/+
) and Nrf2-deficient mice (Nrf2
−/−
) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2
+/+
and Nrf2
−/−
mice. Similar to iNOS result, in Nrf2
−/−
KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2
+/+
WT animals.
4-羟基壬烯醛
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-113466 | 4-Hydroxynonenal | | 1 mg | 480元 |
| 2024/04/30 | HY-113466 | 4-羟基壬烯醛
4-Hydroxynonenal | 75899-68-2 | 5 mg | 1200元 |
4-羟基壬烯醛
生产厂家
全球有 100家供应商
4-羟基壬烯醛国内生产厂家
75899-68-2, 4-羟基壬烯醛 相关搜索:
- 代谢物
- 抗体-一抗
- 小分子
- 试剂盒-Elisa试剂盒
- 生化试剂
- 9001-90-6
- 反式-4-羟基-2-壬烯醛
- 4-羟基壬烯醛抗体
- PE标记的4-羟基壬烯醛抗体
- AF647标记的4-羟基壬烯醛抗体
- ANTI-4 HYDROXYNONENAL ANTIBODY-4-羟基壬烯醛抗体
- 鱼4-羟基壬烯酸(4-HNE)ELISA试剂盒
- 干冰运输]4-羟基壬烯醛
- 4-羟基壬醛
- (E)-4-羟基-2-壬烯醛
- 4-羟基壬烯醛
- 75899-68-2
- Rabbit Anti-4 Hydroxynonenal antibody
- Rabbit Anti-4 Hydroxynonenal/PE Conjugated antibody
- Rabbit Anti-4 Hydroxynonenal/AF647 Conjugated antibody
- biomarker,genotoxic,oxidative,Inhibitor,stress,Cancer,Aldehyde Dehydrogenase (ALDH),4-Hydroxynonenal,Endogenous Metabolite,4Hydroxynonenal,nitrosative,mitochondria,4 Hydroxynonenal,inhibit
- 4-HYDROXYNONENAL
- (E)-4-hydroxynon-2-enal
- 4-HNE
- 4-HYDROXY-2-NONENAL
- HNE ISO 9001：2015 REACH
- Mouse 4-Hydroxy-2-nonenal elisa kit
- 2-Nonenal, 4-hydroxy-, (2E)-
- 4-hydroxy-2-nonena
- (+/-)-4-HYDROXYNON-2-ENAL
- (+/-)-4-HYDROXY-2E-NONENAL
- HNE
- (E)-4-HYDROXYNONENAL
- Ccris 1781