DSR 6434
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- CAS号:
- 1059070-10-8
- 英文名:
- DSR 6434
- 英文别名:
- DSR 6434;DSR6434,DSR 6434;6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one;6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
- 中文名:
- DSR 6434
- 中文别名:
- 化合物 T11108;化合物DSR-6434;DSR 6434,TLR7激动剂;D287770] DSR 6434,TLR7激动剂;6-氨基-2-(丁氨基)-9-((6-(2-(二甲氨基)乙氧基)吡啶-3-基)甲基)-7,9-二氢-8H-嘌呤-8-酮
- CBNumber:
- CB03310328
- 分子式:
- C19H28N8O2
- 分子量:
- 400.48
- MOL File:
- 1059070-10-8.mol
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DSR 6434化学性质
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密度:
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1.283±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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10.22±0.20(Predicted)
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DSR 6434性质、用途与生产工艺
DSR-6434 是一种有效的选择性的 Toll 样受体 7 (TLR7) 激动剂，对人和小鼠 TLR7 的 EC50 分别为 7.2 nM 和 4.6 nM。DSR-6434 具有很强的抗肿瘤作用。
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TLR7
7.2 nM (EC
50
, Human)
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TLR7
4.6 nM (EC
50
, Mice)
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To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. DSR-6434 is capable of stimulating reporter gene activity only in HEK293 cells expressing hTLR7 and not in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.
DSR-6434 treatment (Compound 20; 0.1-1 mg/kg; intravenous injection; biweekly; for 4 weeks; B6C3F1 mice) suppresses the lung metastasis significantly, 78% inhibition at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).
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Animal Model:
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B6C3F1 mice injected with HM-1 ovarian cancer cells
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Dosage:
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0.1 mg/kg, 1 mg/kg
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Administration:
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Intravenous injection; biweekly; for 4 weeks
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Result:
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Suppressed the lung metastasis significantly, 78% inhibition was seen at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).
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DSR 6434
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-110120 | DSR-6434 | | 1 mg | 495元 |
| 2024/04/30 | HY-110120 | DSR 6434
DSR-6434 | 1059070-10-8 | 5mg | 1300元 |
1059070-10-8, DSR 6434 相关搜索:
- 酶
- C19H28N8O2
- DSR 6434,TLR7激动剂
- D287770] DSR 6434,TLR7激动剂
- 化合物DSR-6434
- 6-氨基-2-(丁氨基)-9-((6-(2-(二甲氨基)乙氧基)吡啶-3-基)甲基)-7,9-二氢-8H-嘌呤-8-酮
- 化合物 T11108
- 1059070-10-8
- DSR6434,DSR 6434
- 6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one
- 8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
- 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
- DSR 6434