251994-14-6
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- CAS号:
- 251994-14-6
- 英文名:
- Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-
- 英文别名:
- CAM-IN-1;ICAM-1 inhibitor 1;ICAM 1 IN 1,inhibit,ICAM1IN1,Inhibitor,Integrin;Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-
- 中文名:
- 251994-14-6
- 中文别名:
- 化合物 T13147;化合物ICAM-1-IN-1
- CBNumber:
- CB03339721
- 分子式:
- C15H11BrN2O2S
- 分子量:
- 363.23
- MOL File:
- 251994-14-6.mol
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251994-14-6化学性质
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熔点:
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78-80 °C
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沸点:
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579.6±45.0 °C(Predicted)
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密度:
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1.556±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 135 mg/mL (371.67 mM)
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酸度系数(pKa):
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13.70±0.46(Predicted)
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251994-14-6性质、用途与生产工艺
ICAM-1-IN-1 是有效，选择性的 E-selectin 和 ICAM-1 抑制剂，IC50值分别为7和5 nM。
IC50: 7 nM (E-selectin), 5 nM (ICAM-1)
ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.
251994-14-6
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上游原料
下游产品
251994-14-6, 251994-14-6 相关搜索:
- 对照品
- 化合物ICAM-1-IN-1
- 化合物 T13147
- 251994-14-6
- ICAM 1 IN 1,inhibit,ICAM1IN1,Inhibitor,Integrin
- ICAM-1 inhibitor 1
- CAM-IN-1
- Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-